Sensory perception drives food avoidance through excitatory basal forebrain circuits

eLife

Jessica Swanson¹  Benjamin R Arenkiel²  Elizabeth Hanson³  Joshua Ortiz-Guzman⁴  Kevin Ung⁴  Qingchun Tong⁴  Jay M Patel⁵  Jennifer Selever⁶  Alexander Herman⁶ 

[1] Department of Neuroscience, Baylor College of Medicine, Houston, United States;Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, United States;Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, United States;Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States;Medical Scientist Training Program, Baylor College of Medicine, Houston, United States;Program in Developmental Biology, Baylor College of Medicine, Houston, United States;

关键词: feeding;    basal forebrain;    circuit;    olfactory;    hypothalamus;    cholinergic;   

DOI  :  10.7554/eLife.44548

来源: DOAJ

【 摘 要 】

Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population in the basal forebrain that is activated by food-odor related stimuli, and potently drives hypophagia. Notably, we found that the basal forebrain directly integrates environmental sensory cues to govern feeding behavior, and that basal forebrain signaling, mediated through projections to the lateral hypothalamus, promotes selective avoidance of food and food-related stimuli. Together, these findings reveal a novel role for the excitatory basal forebrain in regulating appetite suppression through food avoidance mechanisms, highlighting a key function for this structure as a potent integrator of sensory information towards governing consummatory behaviors.

【 授权许可】

Unknown