A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

eLife

Miao Jing¹  Tatenda Chakoma²  Yurika Watanabe²  Blaise Robert²  Eyal Y Kimchi³  Daniel B Polley⁴  Yulong Li⁵ 

[1] Chinese Institute for Brain Research, Beijing, China;Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, United States;Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, United States;Department of Neurology, Massachusetts General Hospital, Boston, United States;Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, United States;Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, United States;State Key Laboratory of Membrane Biology, Peking University School of Life Sciences; PKU-IDG/McGovern Institute for Brain Research; Peking-Tsinghua Center for Life Sciences, Beijing, Beijing, China;

关键词: acetylcholine;    cholinergic;    basal forebrain;    auditory;    learning;    Mouse;   

DOI  :  10.7554/eLife.69514

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Basal forebrain cholinergic neurons (BFCNs) project throughout the cortex to regulate arousal, stimulus salience, plasticity, and learning. Although often treated as a monolithic structure, the basal forebrain features distinct connectivity along its rostrocaudal axis that could impart regional differences in BFCN processing. Here, we performed simultaneous bulk calcium imaging from rostral and caudal BFCNs over a 1-month period of variable reinforcement learning in mice. BFCNs in both regions showed equivalently weak responses to unconditioned visual stimuli and anticipated rewards. Rostral BFCNs in the horizontal limb of the diagonal band were more responsive to reward omission, more accurately classified behavioral outcomes, and more closely tracked fluctuations in pupil-indexed global brain state. Caudal tail BFCNs in globus pallidus and substantia innominata were more responsive to unconditioned auditory stimuli, orofacial movements, aversive reinforcement, and showed robust associative plasticity for punishment-predicting cues. These results identify a functional topography that diversifies cholinergic modulatory signals broadcast to downstream brain regions.

【 授权许可】

CC BY