The Role of MiR-124 in Bladder Cancer – A Review of the Literature

Romanian Journal of Laboratory Medicine

Constantinescu Ileana¹  Iacob Maria Mirela¹  Petcu Costin²  Sinescu Ioanel²  Baston Catalin²  Angelescu Emil² 

[1] Center of Immunogenetics and Virology, Fundeni Clinical Institute, Romania;Urological Surgery Department, “Carol Davila” University of Medicine and Pharmacy, Romania;

关键词: bladder cancer;    mir-124;    microrna;    mir-124 target;    mirnas;   

DOI  :  10.2478/rrlm-2021-0001

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) are a group of non-coding RNA molecules that have an important role in modulating the expression of genes involved in regulating cellular functions. A growing number of studies suggest the abnormal expression of microRNAs in different types of cancer cells. MiRNA-124 is a microRNA that is down-regulated in many types of cancer cells, including bladder cancer. Our objective is to provide a review of the key publications that studied the effect of miR-124 on bladder cancer. This review focus on the targets and different pathways of miR-124 that were identified in various studies and differences between their expressions in normal urothelium and tumor tissues. We also include data regarding urinary methylations levels of miR-124 and their role in bladder cancer diagnosis and prognosis. Subsequently, we establish future perspectives of miR-124 research and its promising role in bladder cancer.

【 授权许可】

Unknown