Circular RNAs function as ceRNAs to regulate and control human cancer progression

Molecular Cancer

Xu Wu¹  Fang Wei¹  Chunmei Fan¹  Can Guo¹  Guiyuan Li¹  Yong Li¹  Xiaoling Li¹  Fang Xiong²  Zhaoyang Zeng²  Xin Ye²  Yumin Wang²  Chunwei Li²  Yaxian Zhong²  Yongzhen Mo²  Wei Xiong²  Yajun Du²  Daixi Ren²  Xue Yang² 

[1] The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Basic Medical Science School and Cancer Research Institute, Central South University;The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University;

关键词: Circular RNAs;    ceRNA;    Cancer;    Gene expression regulation;   

DOI  :  10.1186/s12943-018-0827-8

来源: DOAJ

【 摘 要 】

Abstract Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron cyclization, forming a complete ring structure. circRNA is more stable and conservative than linear RNA and abounds in various organisms. In recent years, increasing numbers of reports have found that circRNA plays a major role in the biological functions of a network of competing endogenous RNA (ceRNA). circRNAs can compete together with microRNAs (miRNAs) to influence the stability of target RNAs or their translation, thus, regulating gene expression at the transcriptional level. circRNAs are involved in biological processes such as tumor cell proliferation, apoptosis, invasion, and migration as ceRNAs. circRNAs, therefore, represent promising candidates for clinical diagnosis and treatment. Here, we review the progress in studying the role of circRNAs as ceRNAs in tumors and highlight the participation of circRNAs in signal transduction pathways to regulate cellular functions.

【 授权许可】

Unknown