Circular RNAs in human cancer

Molecular Cancer

Review

Wenling Zhang¹  Yong Li²  Zhaojian Gong³  Qianjin Liao⁴  Xiayu Li⁵  Ming Zhou⁶  Xiang Yang⁷  Fang Xiong⁷  Mo Yang⁷  Shanshan Zhang⁷  Yumin Wang⁸  Wei Xiong⁸  Yongzhen Mo⁸  Bo Xiang⁸  Guiyuan Li⁸  Zhaoyang Zeng⁸  Xiaoling Li⁸ 

[1] Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China;Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China;Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA;Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China;Department of Stomatolog, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China;Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China;Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 410013, Changsha, Hunan, China;Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, 410013, Changsha, Hunan, China;Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, 410013, Changsha, Hunan, China;Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 410013, Changsha, Hunan, China;Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, 410078, Changsha, Hunan, China;Key Laboratory of Carcinogenesis of Ministry of Health, Xiangya Hospital, Central South University, 410078, Changsha, Hunan, China;Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, 410013, Changsha, Hunan, China;

关键词: Circular RNAs;    Cancer;    Splicing;    Biomarker;    Regulation;   

DOI  :  10.1186/s12943-017-0598-7

 received in 2016-12-01, accepted in 2017-01-19,  发布年份 2017

来源: Springer

【 摘 要 】

CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique structure, they are more stable than linear RNAs. CircRNAs play important roles in the carcinogenesis of cancer. The expression of circRNAs is correlated with patients’ clinical characteristics, and circRNAs play a vital role in many aspects of malignant phenotypes, including cell cycle, apoptosis, vascularization, and invasion; metastasis as a RNA sponge, binding to RBP; or translation. Therefore, it is meaningful to further study the mechanism of interactions between circRNAs and tumors. The role of circRNAs as molecular markers or potential targets will provide promising application perspectives, such as early tumor diagnosis, therapeutic evaluation, prognosis prediction, and even gene therapy for tumors.

【 授权许可】

CC BY   
© The Author(s). 2017