Chromosome Territories in Hematological Malignancies

Cells

Mateus de Oliveira Lisboa¹  Lucas E. L. Terceiro²  Sabine Mai³  Aline Rangel-Pozzo³  Matheus Fabiao de Lima³ 

[1] Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica do Paraná—PUCPR, Curitiba 80215-901, Brazil;Department of Pathology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 3P5, Canada;Department of Physiology and Pathophysiology, CancerCare Manitoba Research Institute, University of Manitoba, Winnipeg, MB R3E 0V9, Canada;

关键词: multiple myeloma;    nuclear organization;    genome markers;    leukemia;    lymphoma;    chromosome territories;   

DOI  :  10.3390/cells11081368

来源: DOAJ

【 摘 要 】

Chromosomes are organized in distinct nuclear areas designated as chromosome territories (CT). The structural formation of CT is a consequence of chromatin packaging and organization that ultimately affects cell function. Chromosome positioning can identify structural signatures of genomic organization, especially for diseases where changes in gene expression contribute to a given phenotype. The study of CT in hematological diseases revealed chromosome position as an important factor for specific chromosome translocations. In this review, we highlight the history of CT theory, current knowledge on possible clinical applications of CT analysis, and the impact of CT in the development of hematological neoplasia such as multiple myeloma, leukemia, and lymphomas. Accumulating data on nuclear architecture in cancer allow one to propose the three-dimensional nuclear genomic landscape as a novel cancer biomarker for the future.

【 授权许可】

Unknown