Specialized Intercellular Communications via Tunnelling Nanotubes in Acute and Chronic Leukemia

Cancers

Marco Casciaro¹  Sebastiano Gangemi¹  Claudia Petrarca²  Mario Di Gioacchino²  Alessandro Allegra³  Caterina Musolino³  Gabriella Cancemi³ 

[1] Allergy and Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy;Center for Advanced Studies and Technology, G.d’Annunzio University, 66100 Chieti, Italy;Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, Division of Hematology, University of Messina, 98125 Messina, Italy;

关键词: tunneling nanotubes;    cell communication;    cancer;    hematologic malignancies;    leukemia;    multiple myeloma;   

DOI  :  10.3390/cancers14030659

来源: DOAJ

【 摘 要 】

Effectual cell-to-cell communication is essential to the development and differentiation of organisms, the preservation of tissue tasks, and the synchronization of their different physiological actions, but also to the proliferation and metastasis of tumor cells. Tunneling nanotubes (TNTs) are membrane-enclosed tubular connections between cells that carry a multiplicity of cellular loads, such as exosomes, non-coding RNAs, mitochondria, and proteins, and they have been identified as the main participants in healthy and tumoral cell communication. TNTs have been described in numerous tumors in in vitro, ex vivo, and in vivo models favoring the onset and progression of tumors. Tumor cells utilize TNT-like membranous channels to transfer information between themselves or with the tumoral milieu. As a result, tumor cells attain novel capabilities, such as the increased capacity of metastasis, metabolic plasticity, angiogenic aptitude, and chemoresistance, promoting tumor severity. Here, we review the morphological and operational characteristics of TNTs and their influence on hematologic malignancies’ progression and resistance to therapies, focusing on acute and chronic myeloid and acute lymphoid leukemia. Finally, we examine the prospects and challenges for TNTs as a therapeutic approach for hematologic diseases by examining the development of efficient and safe drugs targeting TNTs.

【 授权许可】

Unknown