Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types

Data in Brief

Yong Zhu¹  Tongzhang Zheng²  Xichi Zhang³  Theodore R. Holford⁴  Stephen Marc Schwartz⁴  Russ Hauser⁵  Bryan Bassig⁶  Kunchong Shi⁷  Chu Chen⁷  Peter Boyle⁸  Bo Yang⁹  Dian Shi⁹  Zhengmin Qian⁹  Zhiyuan Cheng⁹  Elizabeth Zheng^1,10 

[1] School of Basic Medicine, Lanzhou University, Lanzhou, Gansu 730000, China;;Wellbeing College for Public Health &Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, 1518 Clifton Rd, NE, Atlanta, GA 30322, USA;Department of Biostatistics, Yale School of Public Health, Yale University, CT 06510, USA;Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, MA 02115, USA;Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA;Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;;Institute for Global Health &School of Public Health, Brown University, Providence, RI 02903, USA;University of Vermont, Burlington, VT 05405, USA;

关键词: Case-control study;    Endocrine disruptors;    Persistent organic pollutants;    Polychlorinated biphenyl;    Testicular germ cell tumor;   

DOI  :  

来源: DOAJ

【 摘 要 】

In a population-based case control study of testicular germ cell tumors (TGCT), we reported a strong positive association between serum levels of Wolff's Group 1 (potentially estrogenic) polychlorinated biphenyl (PCBs) and risk of TGCT, and the observed associations were similar for both seminoma and non-seminoma. While the observed specific associations between TGCT and Wolff's Group 1 PCBs cannot be easily explained by bias or confounding, a question can still be asked, that is, could the relationship between PCBs and TGCT differ by age at diagnosis? PCBs tend to bioaccumulate, with more heavily chlorinated PCB congeners tending to have longer half-lives. Half-lives of PCB congeners were reported ranging from 4.6 years for PCB-28 to 41.0 years for PCB-156. The half-life for the heavy PCB congeners (17.8 years) was found to be approximately twice that for the light PCBs (9.6 years) in early studies. Therefore, the same PCB concentration measured in a 20-year-old vs. a 55-year-old is unlikely to represent the same lifetime PCB exposure or type of PCB exposure. In this analysis, we stratified the data by median age of diagnosis of TGCT and further stratified by histologic type of TGCT (seminoma vs non-seminoma) to explore if the risk of TGCT associated with PCB exposures differs by age.

【 授权许可】

Unknown