Evidence for the induction of cytochrome P‐452 in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls

FEBS Letters

Wilkins, J.P.G.³  Edwards-Webb, J.D.⁴  Robertson, L.W.²  Dils, R.R.¹  Borlakoglu, J.T.¹ 

[1] Department of Biochemistry & Physiology, University of Reading, Whiteknights, PO Box 228, Reading RG6 2AJ, England;Graduate Center for Toxicology, 204 Funkhouser Building, University of Kentucky, Lexington, KY 40506-0054, USA;MAFF Harpenden Laboratory, Hatching Green, Harpenden, Herts AL5 2BD, England;Department of Human Nutrition, AFRC Institute of Food Research, Reading Laboratory, Shinfield, Berkshire RG2 9AT, England

关键词: Polychlorinated biphenyl;    Cytochrome P-450;    Lauric acid hydroxylation;    Nonradioisotopic assay;    (Rat liver;    Pigeon liver);   

DOI  :  10.1016/0014-5793(89)81362-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have examined the ability of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) to induce hepatic cytochrome P-452-linked enzyme activities in rat and pigeon liver five days after its intraperitoneal injection. The results provide evidence that, at the doses used, Aroclor 1254 induces cytochrome P-452-linked enzyme activities in rats, but not in pigeons. This inductive effect was previously regarded as being specific for hypolipidemic drugs and phthalate ester plasticisers.

【 授权许可】

Unknown