99mTc-MIBI SPECT/CT imaging had high sensitivity in accurate localization of parathyroids before parathyroidectomy for patients with secondary hyperparathyroidism

Renal Failure

Shaowen Tang¹  Lina Zhang²  Ming Zeng³  Guang Yang³  Huijuan Mao³  Ningning Wang³  Xiangbao Yu³  Jing Wang³  Jing Guo³  Chun Ouyang³  Jin Liu³  Yogendranath Purrunsing³  Changying Xing³  Bin Sun³  Bo Zhang³  Xiaoming Zha³  Wei Liu³  Yaoyu Huang³  Hanyang Qian³ 

[1] , Nanjing Medical University;People's Hospital of Zhengzhou University;The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital;

关键词: secondary hyperparathyroidism;    parathyroid;    parathyroidectomy;    dual-phase 99mtc-mibi scintigraphy;    single-photon emission computed tomography/computed tomography imaging;   

DOI  :  10.1080/0886022X.2019.1662804

来源: DOAJ

【 摘 要 】

Purpose: Accurate preoperative parathyroid localization is important for successful parathyroidectomy (PTX). The aim of our study was to investigate whether SPECT/CT has enhanced effect in preoperative localization of parathyroids. Methods: In our retrospective cohort study, we evaluated the effects of technetium-99m methoxyisobutylisonitrile-single-photon emission computed tomography/computed tomography (99mTc-MIBI SPECT/CT) on preoperative parathyroid localization for 645 secondary hyperparathyroidism (SHPT) patients. Among them, 569 successful PTX patients were divided into group A (received 99mTc-MIBI scintigraphy, n = 175) and group B (received 99mTc-MIBI scintigraphy and SPECT/CT imaging, n = 394). Sensitivity, specificity, and consistency of two imaging methods in preoperative localization of parathyroids were compared. Results: Overall sensitivity and consistency were higher in group B, while there was no difference in specificity between the two groups. In group A, the sensitivity of 99mTc-MIBI was 50.00%, 77.11%, 61.76%, and 76.54% in the right upper gland (RU), right lower gland (RL), left upper gland (LU), and left lower gland (LL) subgroups, while the consistency was 52.00%, 76.57%, 61.71%, and 75.43%, respectively. In group B, the sensitivity of 99mTc-MIBI with SPECT/CT was 69.39%, 90.03%, 78.07%, and 84.27%, and the consistency was 69.54%, 88.32%, 78.43%, and 84.26%, respectively. The sensitivity and consistency in lower glands were higher than in upper glands in both groups. Sensitivity for eutopic parathyroid was higher in group B, while there was no difference for ectopic parathyroid. Conclusions: 99mTc-MIBI SPECT/CT can increase the sensitivity and consistency of preoperative localization of eutopic parathyroid glands, and it can accurately locate ectopic parathyroid without sensitivity improvement.

【 授权许可】

Unknown