Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids

Molecules

Mengbi Guo¹  Chun Guo¹  Hang Xu¹  Xin Su²  Ye Tian²  Zhen Liang² 

[1] Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;;Key Laboratory of Structure-Based Drugs Design &

关键词: antifungal activity;    N-myristoyltransferase;    benzofuran;    1,2,3-triazole;    click chemistry;    molecule hybrid;   

DOI  :  10.3390/molecules21060732

来源: DOAJ

【 摘 要 】

A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds exhibited moderate to satisfactory activity. Furthermore, molecular docking was performed to investigate the binding affinities and interaction modes between the target compound and N-myristoyltransferase. Based on the results, preliminary structure activity relationships (SARs) were summarized to serve as a foundation for further investigation.

【 授权许可】

Unknown