Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study

Journal of Imaging

Sara Mercogliano¹  Rossella Rella²  Marta Mandarà³  Lisa Zantedeschi⁴  Francesca Fornasa⁴  Andrea Caneva⁵  Chiara Benassuti⁶  Loredana Cugola⁷  Maria Vittoria Bisighin⁷  Giovanna Romanucci⁷  Anna Ventriglia⁷  Paola Bricolo⁷ 

[1] A Division of Radiology, Ospedale Medico-Chirurgico Accreditato Villa dei Fiori, Acerra, 80011 Naples, Italy;Department of Diagnostic Imaging, G.B. Grassi Hospital, ASL ROMA 3, Via Gian Carlo Passeroni, 28, 00122 Rome, Italy;Department of Medical Oncology, ULSS9 Scaligera, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, Italy;Department of Radiology, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, Italy;Division of Pathology, ULSS9 Scaligera, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, Italy;UOSD Breast Surgery, ULSS9 Scaligera, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, Italy;UOSD Breast Unit ULSS9, Ospedale di Marzana, Piazzale Lambranzi, 1, 37142 Verona, Italy;

关键词: digital breast tomosynthesis;    invasive lobular carcinoma;    breast cancer;    conspicuity;   

DOI  :  10.3390/jimaging7090185

来源: DOAJ

【 摘 要 】

Objectives: To compare the conspicuity of lobular breast cancers at digital breast tomosynthesis (DBT) versus synthesized 2D mammography (synt2D). Materials and methods: Seventy-six women (mean age 61.2 years, range 50–74 years) submitted to biopsy in our institution, from 2019 to 2021, with proven invasive lobular breast cancer (ILC) were enrolled in this retrospective study. The participants underwent DBT and synt2D. Five breast radiologists, with different years of experience in breast imaging, independently assigned a conspicuity score (ordinal 6-point scale) to DBT and synt2D. Lesion conspicuity was compared, for each reader, between the synt2D overall conspicuity interpretation and DBT overall conspicuity interpretation using a Wilcoxon matched pairs test. Results: A total of 50/78 (64%) cancers were detected on both synt2D and DBT by all the readers, while 28/78 (26%) cancers where not recognized by at least one reader on synt2D. For each reader, in comparison with synt2D, DBT increased significantly the conspicuity of ILC (p < 0.0001). The raw proportion of high versus low conspicuity by modality confirmed that cancers were more likely to have high conspicuity at DBT than synt2D. Conclusions: ILCs were more likely to have high conspicuity at DBT than at synt2D, increasing the chances of the detection of ILC breast cancer.

【 授权许可】

Unknown