Plants of the Annonaceae traditionally used as antimalarials: a review

Revista Brasileira de Fruticultura

Adrian Martin Pohlit¹  Gina Frausin²  Ari de Freitas Hidalgo³  Renata Braga Souza Lima³  Paul Maas⁴ 

[1] National Institute for Amazon Research;Research Network on Chemical Compounds from Plants of Ethnopharmacological Origin for Malaria Control in the States of Amazonas and Acre;Universidade Federal do Amazonas;Wageningen University;

关键词: Malária;    Plasmodium falciparum;    Plasmodium yoelii nigeriensis;   

DOI  :  10.1590/S0100-29452014000500038

来源: DOAJ

【 摘 要 】

Species of the Annonaceae family are used all over the tropics in traditional medicine in tropical regions for the treatment of malaria and other illnesses. Phytochemical studies of this family have revealed chemical components which could offer new alternatives for the treatment and control of malaria. Searches in scientific reference sites (SciFinder Scholar, Scielo, PubMed, ScienceDirect and ISI Web of Science) and a bibliographic literature search for species of Annonaceae used traditionally to treat malaria and fever were carried out. This family contains 2,100 species in 123 genera. We encountered 113 articles reporting medicinal use of one or more species of this family including 63 species in 27 genera with uses as antimalarials and febrifuges. Even though the same species of Annonaceae are used by diverse ethnic groups, different plant parts are often chosen for applications, and diverse methods of preparation and treatment are used. The ethanol extracts of Polyalthia debilis and Xylopia aromatica proved to be quite active against Plasmodium falciparum in vitro (median inhibition concentration, IC50 < 1.5 µg/mL). Intraperitoneal injection of Annickia chlorantha aqueous extracts (cited as Enantia chlorantha) cleared chloroquine-resistant Plasmodium yoelii nigeriensis from the blood of mice in a dose-dependant manner. More phytochemical profiles of Annonaceous species are required; especially information on the more commonly distributed antimalarial compounds in this family.

【 授权许可】

Unknown