The Digital Brain Bank, an open access platform for post-mortem imaging datasets

eLife

Istvan N Huszar¹  Martijn P van den Heuvel²  Rogier B Mars³  Adele Smart⁴  Mads F Bertelsen⁵  Amy FD Howard⁶  Martin R Turner⁶  Ricarda AL Menke⁷  Sarah Bangerter-Christensen⁷  Olaf Ansorge⁷  Jerome Sallet⁷  Chaoyue Wang⁷  Paul R Manger⁸  Gregory S Berns⁹  Jeroen Mollink^1,10  Connor Scott^1,11  Lianne H Scholtens^1,11  Taylor Hanayik^1,12  Sean Foxley^1,12  Katherine L Bryant^1,12  Alexandre A Khrapitchev^1,12  Menuka Pallebage-Gamarallage^1,12  Saad Jbabdi^1,12  Karla L Miller^1,12  Duncan Mortimer^1,12  Anna Leonte^1,12  Lea Roumazeilles^1,12  Benjamin C Tendler^1,12 

[1] Department of Child Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands;Department of Radiology, University of Chicago, Chicago, United States;Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;Stem Cell and Brain Research Institute, Université Lyon 1, INSERM, Bron, France;Centre for Zoo and Wild Animal Health, Copenhagen Zoo, Frederiksberg, Denmark;Department of Complex Trait Genetics, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands;Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom;Psychology Department, Emory University, Atlanta, United States;School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa;Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom;Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;

关键词: post-mortem;    human neuroanatomy;    comparative neuroanatomy;    neuropathology;    data resource;    Microscopy;   

DOI  :  10.7554/eLife.73153

来源: DOAJ

【 摘 要 】

Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes—Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; and Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank data release includes 21 distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen nonhuman primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The Digital Brain Bank is the culmination of our lab’s investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the Digital Brain Bank provides cross-scale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies.

【 授权许可】

Unknown