The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Acta Neuropathologica Communications

Eugeen Vanmechelen¹  Philipp O. Tsvetkov²  François Devred²  Miguel Medina³  Youssra K. Al-Hilaly⁴  Louise Serpell⁴  Yann Fichou⁵  Joke Verelst⁶  Joris Winderickx⁶  Audrey Perrotin⁷  Bernard J Hanseeuw⁸  Nick Geukens⁹  Caroline Smet-Nocca^1,10  Isabelle Landrieu^1,10  Luc Buée^1,11 

[1] ADx NeuroSciences NV;Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, Fac Pharm;CIBERNED (Network Center for Biomedical Research in Neurodegenerative Diseases);Dementia Research group, School of Life Sciences, University of Sussex;Department of chemistry and biochemistry, University of California Santa Barbara;Functional Biology, KU Leuven;Life Molecular Imaging;Neurology Department, Cliniques Universitaires Saint-Luc;Pharmabs, KU Leuven;University of Lille, CNRS, UMR8576;University of Lille, Inserm, CHU-Lille, UMRS1172;

关键词: Tauopathies;    Alzheimer’s disease;    tau structure;    tau aggregation;    Alzheimer’s disease diagnosis;    Amyloid;   

DOI  :  10.1186/s40478-019-0682-x

来源: DOAJ

【 摘 要 】

Abstract Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer’s and Pick’s disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as the tau protein itself takes many forms. We will here address a range of studies that help to define the many facets of tau protein structures and how they translate into pathogenic forms. New results shed light on previous data that need now to be revisited in order to up-date our knowledge of tau molecular structure. Finally, we explore how these data can contribute the important medical aspects of this research - diagnosis and therapeutics.

【 授权许可】

Unknown