Mammillary bodies and fornix fibers are injured in heart failure

Neurobiology of Disease

Michele A. Hamilton¹  Bramley V.X. Birrer²  Paul M. Macey³  Rajesh Kumar³  Ronald M. Harper⁴  Mary A. Woo⁵  Gregg C. Fonarow⁵ 

[1] Brain Research Institute, Los Angeles, CA 90095, USA;Corresponding author. Fax: [phone].;Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;UCLA School of Nursing, University of California at Los Angeles, 700 Tiverton Avenue, Los Angeles, CA 90095-1702, USA;

关键词: Anterior thalamus;    Magnetic resonance imaging;    Hippocampus;    Thiamine;    Ischemia;    Memory;   

DOI  :  

来源: DOAJ

【 摘 要 】

Cognitive abnormalities, including memory deficits, are common in heart failure (HF). Brain structures, including the hippocampus, fornix, and thalamus participate in memory processing, and most show structural injury and functional deficits in HF. The mammillary bodies and fornix play essential roles in spatial and working memory processing, interact with other structures, and may also be injured in HF. We assessed mammillary body volumes and cross-sectional fornix areas in 17 HF and 50 control subjects using high-resolution T1-weighted magnetic resonance images. Mammillary body volumes and fornix cross-sectional areas were significantly reduced bilaterally in HF, and these differences remained after controlling age, gender, and intracranial volume. Mammillary body and fornix injury may contribute to the compromised spatial and working memory deficits in HF. Pathological processes eliciting the damage may include injury accompanying hypoxic/ischemic processes in pathologic HF perfusion and breathing, and thiamine deficiency accompanying diuretic use and nutritional mal-absorption in the condition.

【 授权许可】

Unknown