Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome

Microorganisms

Isabel Moreno-Indias¹  Dolores Corella¹  Olga Castañer¹  Montserrat Fitó¹  MiguelAngel Martínez-González¹  FranciscoJosé Tinahones¹  Rebeca Fernández-Carrión¹  Nancy Babio²  Jananee Muralidharan²  Monica Bulló²  Jordi Salas-Salvadó²  Alessandro Atzeni²  Serena Galié²  Romina Olbeyra³  Josep Vidal³  Jesús Vioque⁴  Laura Torres-Collado⁴ 

[1] CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain;Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43201 Reus, Spain;Endocrinology and Nutrition Department, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic Universitari, 08036 Barcelona, Spain;Instituto de Investigación Sanitaria y Biomédica de Alicante, ISABIAL-UMH, 03010 Alicante, Spain;

关键词: obesity;    gut microbiota;    BMI;    weight loss;    16S sequencing;    clinical trial;   

DOI  :  10.3390/microorganisms9020346

来源: DOAJ

【 摘 要 】

Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55–75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.

【 授权许可】

Unknown