New insights into bacterial type II polyketide biosynthesis [version 1; referees: 2 approved]

F1000Research

Hai-Xue Pan¹  Gong-Li Tang¹  Zhuan Zhang¹ 

[1] State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China;

关键词: Applied Microbiology;    Biocatalysis;    Directed Molecular Evolution;    Macromolecular Assemblies & Machines;    Microbial Physiology & Metabolism;    Small Molecule Chemistry;   

DOI  :  10.12688/f1000research.10466.1

来源: DOAJ

【 摘 要 】

Bacterial aromatic polyketides, exemplified by anthracyclines, angucyclines, tetracyclines, and pentangular polyphenols, are a large family of natural products with diverse structures and biological activities and are usually biosynthesized by type II polyketide synthases (PKSs). Since the starting point of biosynthesis and combinatorial biosynthesis in 1984–1985, there has been a continuous effort to investigate the biosynthetic logic of aromatic polyketides owing to the urgent need of developing promising therapeutic candidates from these compounds. Recently, significant advances in the structural and mechanistic identification of enzymes involved in aromatic polyketide biosynthesis have been made on the basis of novel genetic, biochemical, and chemical technologies. This review highlights the progress in bacterial type II PKSs in the past three years (2013–2016). Moreover, novel compounds discovered or created by genome mining and biosynthetic engineering are also included.

【 授权许可】

Unknown