Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine

Genes and Diseases

Russell R. Reid¹  Elliot S. Bishop¹  Ying Wu²  Shujuan Yan²  Jiayan Lei²  Sherwin Ho²  Xinyi Yu²  Zongyue Zeng²  Ke Wu²  Xingye Wu²  Michael J. Lee²  Yasha Li²  Aravind Athiviraham²  Jennifer Moriatis Wolf²  Chen Zhao²  Ruyi Zhang²  Wenwen Zhang²  Yi Shu²  Chao Yang²  Tong-Chuan He²  Evan M. Farina³  Cody S. Lee³ 

[1] Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA;Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA;The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA;

关键词: Adenovirus;    Adenoviral vector;    Cell therapy;    Gene transfer;    Gene therapy;    Oncolytic virus;    Regenerative medicine;    Vaccine development;   

DOI  :  10.1016/j.gendis.2017.04.001

来源: DOAJ

【 摘 要 】

With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology, it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies. Despite numerous setbacks, efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases. It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies. There has been a long-lasting interest in using viral vectors, especially adenoviral vectors, to deliver therapeutic genes for the past two decades. Among all currently available viral vectors, adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types. The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development. In fact, among over 2000 gene therapy clinical trials approved worldwide since 1989, a significant portion of the trials have utilized adenoviral vectors. This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors, including adenoviral biology, approaches to engineering adenoviral vectors, and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment, vaccination and regenerative medicine. Current challenges and future directions regarding the use of adenoviral vectors are also discussed. It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine.

【 授权许可】

Unknown