Cerebrovascular Function in the Large Arteries Is Maintained Following Moderate Intensity Exercise

Frontiers in Physiology

Kevin Murphy¹  Jessica J. Steventon¹  Joseph R. Whittaker¹  Alex B. Hansen²  Daniela Nowak-Flück²  Kevin W. Wildfong²  Phil N. Ainslie²  Michael M. Tymko² 

[1] Cardiff University Brain Research Imaging Centre, School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom;Centre for Heart Lung and Vascular Health, School of Health and Exercise Science, University of British Columbia Okanagan, Kelowna, BC, Canada;Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom;

关键词: PETCO2;    cerebrovascular reactivity;    cerebral blood flow;    exercise;    haemodynamics;    cerebral plasticity;   

DOI  :  10.3389/fphys.2018.01657

来源: DOAJ

【 摘 要 】

Exercise has been shown to induce cerebrovascular adaptations. However, the underlying temporal dynamics are poorly understood, and regional variation in the vascular response to exercise has been observed in the large cerebral arteries. Here, we sought to measure the cerebrovascular effects of a single 20-min session of moderate-intensity exercise in the one hour period immediately following exercise cessation. We employed transcranial Doppler (TCD) ultrasonography to measure cerebral blood flow velocity (CBFV) in the middle cerebral artery (MCAv) and posterior cerebral artery (PCAv) before, during, and following exercise. Additionally, we simultaneously measured cerebral blood flow (CBF) in the internal carotid artery (ICA) and vertebral artery (VA) before and up to one hour following exercise cessation using Duplex ultrasound. A hypercapnia challenge was used before and after exercise to examine exercise-induced changes in cerebrovascular reactivity (CVR). We found that MCAv and PCAv were significantly elevated during exercise (p = 4.81 × 10-5 and 2.40 × 10-4, respectively). A general linear model revealed that these changes were largely explained by the partial pressure of end-tidal CO2 and not a direct vascular effect of exercise. After exercise cessation, there was no effect of exercise on CBFV or CVR in the intracranial or extracranial arteries (all p > 0.05). Taken together, these data confirm that CBF is rapidly and uniformly regulated following exercise cessation in healthy young males.

【 授权许可】

Unknown