The Role of Aldosterone in OSA and OSA-Related Hypertension

Frontiers in Endocrinology

Chuan Xiang Li²  Yi Wang⁴  Shi Qi Li⁴  Ya Ru Yan⁴  Li Yue Zhang⁴  Liu Zhang⁴  Ning Li⁴  Ying Ni Lin⁴  Fang Ying Lu⁴  Qing Yun Li⁴ 

[1] Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Respiratory and Critical Care Medicine, Tongren Hospital Affiliated to Wuhan University, The Third Hospital of Wuhan, Wuhan, China;Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Ruijin Hospital, Shanghai, China;

关键词: obstructive sleep apnea;    aldosterone;    hypertension;    continuous positive airway pressure (CPAP);    mineralocorticoid receptor antagonists;   

DOI  :  10.3389/fendo.2021.801689

来源: DOAJ

【 摘 要 】

Obstructive sleep apnea (OSA) is regarded as an independent risk factor for hypertension. The possible mechanism includes oxidative stress, endothelial injury, sympathetic excitement, renin–angiotensin–aldosterone system activation, etc. Clinical studies have found that there is a high coexistence of OSA and primary aldosteronism in patients with hypertension and that elevated aldosterone levels are independently associated with OSA severity in resistant hypertension. The underlying mechanism is that aldosterone excess can exacerbate OSA through increasing overnight fluid shift and affecting the mass and function of upper airway muscles during the sleep period. Thus, a bidirectional influence between OSA and aldosterone exists and contributes to hypertension in OSA patients, especially resistant hypertension.

【 授权许可】

Unknown