CYLD expression in endometrial carcinoma and correlation with clinicohistopathological parameters

Taiwanese Journal of Obstetrics & Gynecology

Theodora-Eleftheria Deftereou¹  Triantafyllos Alexiadis²  Stylianos Tologkos³  Anastasios Liberis³  Vasiliki Papadatou³  Christina-Angelika Alexiadi³  Avgi Tsolou³  Christina Nikolaidou³  Maria Lambropoulou³  Kyriaki Georgiadi⁴  Grigorios Trypsianis⁵ 

[1] Corresponding author. Democritus University of Thrace, Dragana, 68100, Alexandroupolis, Greece. Fax: [phone].;Gynecology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece;Laboratory of Histology-Embryology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;Medical Statistics, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;;Second Department of Obstetrics &

关键词: Biomarker;    Cylidromatosis gene;    Endometrial cancer;    Prognosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: Endometrial cancer is a threat to women health worldwide. Cylindromatosis (CYLD) enzyme is a tumour suppressor, considered an effective prognostic marker in various malignancies, but its role in endometrial carcinoma is not fully elucidated. Here, we sought to estimate the prognostic value of CYLD expression in endometrial carcinoma. Materials and methods: CYLD levels were immunohistochemically evaluated in 65 patients with endometrial carcinoma and inferential statistics were applied. Results: Low or negative CYLD expression significantly correlates with older ages, non-endometrioid and invasive carcinomas, tumours with moderate or poor differentiation and advanced stages. Moreover, non-endometrioid and invasive carcinomas are independent risk factors for weaker CYLD expression. Kaplan–Meier analysis illustrated that negative or low CYLD expression is statistically significantly associated with increased death risk, compared to moderate or high expression. Conclusion: This study demonstrates for the first time a clear correlation between CYLD expression and clinicohistopathological parameters of endometrial carcinoma patients, suggesting its use as a potential prognostic/predictive marker for Endometrial Carcinoma.

【 授权许可】

Unknown