Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancy

Neurobiology of Stress

Nina Pettersson¹  Eeva Ekholm²  Minna Kyläniemi³  Mikko Konki⁴  Riikka J. Lund⁵  Hasse Karlsson⁵  Riina Kaukonen⁶  Linnea Karlsson⁶  Noora M. Scheinin⁶ 

[1] Corresponding author. Turku Bioscience Centre, University of Turku, Tykistökatu 6A, FI-20520, Turku, Finland.;Department of Psychiatry and Turku Brain and Mind Centre, University of Turku and Turku University Hospital, Turku, Finland;Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland;Department of Obstetrics and Gynecology, Turku University Central Hospital and University of Turku, Turku, Finland;FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland;Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland;

关键词: Depressive symptoms;    Pregnancy;    Epigenome;    DNA methylation;    Placenta;    Enhancer;   

DOI  :  

来源: DOAJ

【 摘 要 】

Maternal depressive symptoms during pregnancy are a significant risk factor for adverse developmental and health outcomes of the offspring. The molecular mechanisms mediating the long-term effects of this exposure are not well understood. Previous studies have found association between prenatal exposure to maternal psychological distress and placental DNA methylation of candidate genes, which can influence placental barrier function and development of the fetus. Our objective in this study was to determine epigenome wide association of maternal depressive symptoms in early pregnancy with the placental DNA methylation. For this purpose we examined DNA methylomes of 92 placental samples by using reduced representation bisulfite sequencing. The placental samples were collected after deliveries of 39 girls and 59 boys, whose mothers had Edinburgh Postnatal Depression Score ranging from 0 to 19 at gestational week 14. According to our results maternal depressive symptoms are associated with DNA methylation of 2833 CpG sites, which are particularly over-represented in genic enhancers. The genes overlapping or nearest to these sites are functionally enriched for development of neurons and show expression enrichment in several regions of developing brain. The genomic regions harboring the DNA methylation marks are enriched for single nucleotide polymorphisms associated with mental disease trait class. Potential cellular signaling cascades mediating the effects include inflammatory and hormonal pathways. As a conclusion our results suggest that maternal depressive symptoms during early pregnancy are associated with DNA methylation marks in placenta in genes, which are important for the development and long-term health of the brain. Whether similar marks can be detected in exposed children remains to be elucidated in further studies.

【 授权许可】

Unknown