Iron-Uptake Systems of Chicken-Associated Salmonella Serovars and their Role in Colonizing the Avian Host

Microorganisms

DineshH. Wellawa¹  Wolfgang Köster¹  Brenda Allan¹  Aaron White¹ 

[1] Vaccine & Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, S7N 5E3 SK, Canada;

关键词: Salmonella;    iron homeostasis and regulation;    chicken;    pathogenicity;    iron transport;   

DOI  :  10.3390/microorganisms8081203

来源: DOAJ

【 摘 要 】

Iron is an essential micronutrient for most bacteria. Salmonella enterica strains, representing human and animal pathogens, have adopted several mechanisms to sequester iron from the environment depending on availability and source. Chickens act as a major reservoir for Salmonella enterica strains which can lead to outbreaks of human salmonellosis. In this review article we summarize the current understanding of the contribution of iron-uptake systems to the virulence of non-typhoidal S. enterica strains in colonizing chickens. We aim to address the gap in knowledge in this field, to help understand and define the interactions between S. enterica and these important hosts, in comparison to mammalian models.

【 授权许可】

Unknown