Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages

Antioxidants

Yongchun Liu¹  Li Ma¹  Yu Qi²  Yucai Chen²  Xu Yan²  Sijin Liu² 

[1] Aerosol and Haze Laboratory, Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China;State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;

关键词: air pollution;    particulate matters;    ageing process;    macrophage;    immune balance;   

DOI  :  10.3390/antiox11040754

来源: DOAJ

【 摘 要 】

There are still significant concerns about the detrimental effects and health risks of particulate matters (PMs) on the respiratory system. Notably, a largely overlooked knowledge gap is whether the environmental ageing process would change the physicochemical properties of PMs as well as the toxic influences of PMs on macrophages. Here, we applied ambient treatment of model PMs to mimic the real O₃-induced ageing process and investigated ageing-determined cytotoxicity profile changes of PMs towards macrophages. The consequent distinct bioreactivity and toxicity towards macrophages are largely attributed to the changes of species of surface O-functional groups. Importantly, we unveiled the specific interactions between aged PMs and macrophages due to the variant contents of the surface carboxyl group, resulting in the divergent inflammatory activations and immune balance in the lung. Collectively, this study unearths the significance of ageing in altering particle cytotoxicity, and also provides additional understandings for consecutive investigations on the adverse effects of air pollution on the respiratory system.

【 授权许可】

Unknown