Class I MHC Polymorphisms Associated with Type 2 Diabetes in the Mexican Population

Genes

Raúl C. Baptista-Rosas¹  Arieh Roldán Mercado-Sesma¹  Luis Daniel Hernandez-Ortega²  Celso Cortés-Romero³  Antonio de Jesus Casillas-Navarro⁴  Adriana Lizeth Morales-Fernández⁴  Laura Yareni Zuñiga⁴  María Guadalupe Sanchez Parada⁴  María Isabel Flores-Echiveste⁴  Mildred Alejandra López-Olaiz⁵  Paola Mendoza-Ramírez⁶  Marco Andrés Pérez-Rodríguez⁷  Felipe de Jesús Orozco-Luna⁷ 

[1] Centro de Investigación Multidisciplinaria en Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá 45425, Mexico;Departamento de Ciencias Biomédicas, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá 45425, Mexico;Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara 44430, Mexico;Escuela de Medicina, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá 45425, Mexico;Escuela de Nutrición, Universidad del Valle de Atemajac, Zapopan 45037, Mexico;Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla, Puebla 72570, Mexico;Programa de Doctorado en Tecnologías de la Información y Centro de Análisis de Datos y Supercómputo, Universidad de Guadalajara, Zapopan 45100, Mexico;

关键词: HLA;    MHC class I;    polymorphism;    variant;    type 2 diabetes;    Mexican;   

DOI  :  10.3390/genes13050772

来源: DOAJ

【 摘 要 】

Type 2 diabetes (T2D) has been linked to the expression of Human Leukocyte Antigens, principally to the Major Histocompatibility Complex Class II, with only scarce reports of Major Histocompatibility Complex Class I in specific populations. The objective of the present work was to explore the presence of polymorphisms in the MHC Class I related to T2D in the Mexican population using the Genome-Wide Association Studies Slim Initiative in Genomic Medicine of the Americas (GWAS SIGMA) database. This database contains information on 3848 Mexican individuals with T2D and 4366 control individuals from the same population without a clinical or hereditary history of the disease. The searching criteria considered a p-value of <0.005 and an odds ratio (OR) of >1.0. Ten novel, statistically significant nucleotide variants were identified: four polymorphisms associated with HLA-A (A*03:01:01:01) and six with HLA-C (C*01:02:01:01). These alleles have a high prevalence in Latin American populations and could potentially be associated with autoimmunity mechanisms related to the development of T2D complications.

【 授权许可】

Unknown