Genetic susceptibility to HPV infection and cervical cancer

Brazilian Journal of Medical and Biological Research

P.c. Maciag¹  L.l. Villa¹ 

[1],Instituto Ludwig de Pesquisa sobre o CâncerSão Paulo SP ,Brasil

关键词: human papillomavirus;    cervical cancer;    HLA;    p53;    polymorphism;   

DOI  :  10.1590/S0100-879X1999000700017

来源: SciELO

【 摘 要 】

Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation.

【 授权许可】

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