Effect of Helicobacter pylori eradication on reflux esophagitis and GERD symptoms after endoscopic resection of gastric neoplasm: a single-center prospective study

BMC Gastroenterology

Sun Ok Kim¹  Hwoon-Yong Jung²  Ji Yong Ahn²  Se Jeong Park²  Gin Hyug Lee²  Jeong Hoon Lee²  Ho June Song²  Kee Don Choi²  Hee Kyong Na²  Do Hoon Kim²  Kee Wook Jung²  Hee Jung Park² 

[1] Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center;Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center;

关键词: Helicobacter pylori;    Eradication;    Reflux esophagitis;    Gastroesophageal reflux;   

DOI  :  10.1186/s12876-020-01276-1

来源: DOAJ

【 摘 要 】

Abstract Background The association between Helicobacter pylori and reflux esophagitis (RE) remains controversial. This study aimed to prospectively evaluate the effect of H. pylori eradication on RE and gastroesophageal reflux (GERD) symptoms in H. pylori-positive patients who underwent endoscopic resection of gastric neoplasm. Methods Of the 244 patients enrolled in this study, 173 H. pylori-positive patients underwent follow-up at least once. We evaluated the prevalence of RE and GERD symptoms in these patients following H. pylori eradication. Results There were 75.7% (131/173), 78.6% (125/159), and 78.9% (105/133) subjects who were successfully eradicated after 6, 12, and 18–24 months, respectively. During the 2-year follow-up period, the eradication of H. pylori did not increase the incidence of RE (OR 0.93; 95% CI, 0.49–1.77, p = 0.828). H. pylori status was also not associated with the development of GERD symptoms (OR 1.12; 95% CI, 0.47–2.95, p = 0.721). In the univariate analysis for RE, present smoking history (OR 4.79; 95% CI 1.98–11.60, p = 0.001), present alcohol consumption history (OR 2.18; 95% CI 1.03–4.63, p = 0.041), and diabetes mellitus (OR 2.44; 95% CI 1.02–5.86, p = 0.045) were found to be associated with RE. Multivariate analysis showed that present smoking history (OR 4.54; 95% CI 1.84–11.02, p = 0.001) was a significant risk factor for RE. Conclusions H. pylori eradication did not increase the incidence of RE or GERD symptoms in patients who underwent endoscopic resection of gastric neoplasm.

【 授权许可】

Unknown