Nutritional Signaling via Free Fatty Acid Receptors

International Journal of Molecular Sciences

Sae Hasegawa¹  Ikuo Kimura¹  Junki Miyamoto¹  Mayu Kasubuchi¹  Akira Nakajima¹  Atsuhiko Ichimura² 

[1] Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-0057, Japan;Department of Biological Chemistry, Graduate School of Pharmaceutical Science, Kyoto University, Kyoto 606-8501, Japan;

关键词: FFAR;    fatty acids;    GPR120;    GPR41;    GPR43;    GPR40;   

DOI  :  10.3390/ijms17040450

来源: DOAJ

【 摘 要 】

Excess energy is stored primarily as triglycerides, which are mobilized when demand for energy arises. Dysfunction of energy balance by excess food intake leads to metabolic diseases, such as obesity and diabetes. Free fatty acids (FFAs) provided by dietary fat are not only important nutrients, but also contribute key physiological functions via FFA receptor (FFAR)-mediated signaling molecules, which depend on FFAs’ carbon chain length and the ligand specificity of the receptors. Functional analyses have revealed that FFARs are critical for metabolic functions, such as peptide hormone secretion and inflammation, and contribute to energy homeostasis. In particular, recent studies have shown that the administration of selective agonists of G protein-coupled receptor (GPR) 40 and GPR120 improved glucose metabolism and systemic metabolic disorders. Furthermore, the anti-inflammation and energy metabolism effects of short chain FAs have been linked to the activation of GPR41 and GPR43. In this review, we summarize recent progress in research on FFAs and their physiological roles in the regulation of energy metabolism.

【 授权许可】

Unknown