Perspectives on the therapeutic potential of short-chain fatty acid receptors

BMB Reports

Bi Oh Park^1,5³  Young Shin Kwak^6⁴  Jeong-Hoon Kim^2,4⁵  Sunhong Kim^1,3⁶ 

[1] College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763^5;College of Pharmacy, Korea University, Sejong 339-700, Korea^6;Department of Biomolecular Science^3;Department of Functional Genomics, University of Science and Technology, Daejeon 305-350^4;Medical Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Chungbuk 363-883^2;Targeted Medicine Research Center^1

关键词: GPR41;   

DOI  :  

学科分类：生物化学/生物物理

来源: Korean Society for Biochemistry and Molecular Biology

【 摘 要 】

There is rapidly growing interest in the human microbiome because of its implication in metabolic disorders and inflammatory diseases. Consequently, understanding the biology of short chain fatty acids and their receptors has become very important for identifying novel therapeutic avenues. GPR41 and GPR43 have been recognized as the cognate receptors for SCFAs and their roles in metabolism and inflammation have drawn much attention in recent years. GPR43 is highly expressed on immune cells and has been suggested to play a role in inflammatory diseases such as inflammatory bowel disease. Both GPR41 and GPR43 have been implicated in diabetes and obesity via the regulation of adipose tissue and gastrointestinal hormones. So far, many studies have provided contradictory results, and therefore further research is required to validate these receptors as drug targets. We will also discuss the synthetic modulators of GPR41 and GPR43 that are critical to understanding the functions of these receptors.

【 授权许可】

Unknown