TGFβ/BMP Signaling Pathway in Cartilage Homeostasis

Cells

ArjanP.M. van Caam¹  NathalieG.M. Thielen¹  PeterM. van der Kraan¹ 

[1] Experimental Rheumatology, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands;

关键词: transforming growth factor β;    bone morphogenetic proteins;    osteoarthritis;    cartilage;    SMADs;    aging;    joint loading;    inflammation;    linker modifications;   

DOI  :  10.3390/cells8090969

来源: DOAJ

【 摘 要 】

Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by growth factors such as those of the transforming growth factor β (TGFβ) family. Members of this family include the TGFβs, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). Signaling by this protein family uniquely activates SMAD-dependent signaling and transcription but also activates SMAD-independent signaling via MAPKs such as ERK and TAK1. This review will address the pivotal role of the TGFβ family in cartilage biology by listing several TGFβ family members and describing their signaling and importance for cartilage maintenance. In addition, it is discussed how (pathological) processes such as aging, mechanical stress, and inflammation contribute to altered TGFβ family signaling, leading to disturbed cartilage metabolism and disease.

【 授权许可】

Unknown