Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert

Annals of Hepatology

Diego Luz Felipe da Silva¹  Max Diego Cruz Santos²  Ingrid de Campos Albuquerque²  Rodrigo de Carvalho Santana³  Antônio Augusto Moura da Silva⁴  Ilana Mirian Almeida Felipe⁵  Adalgisa de Souza Paiva Ferreira⁵  João Renato Rebello Pinho⁶  Ana de Lourdes Candolo Martinelli⁷  Arlene de Jesus Mendes Caldas⁸  Maria Josélia Diniz Moraes⁸  Lena Maria Barros Fonseca⁸  Letícia Alana Barros Souza⁸  Marinilde Teles Souza⁸  Beatriz Rossetti Ferreira⁹  Jomar Diogo Costa Nunes^1,10  Thais Feres Moreira Lima^1,11  Michele Soares Gomes Gouvêa^1,11  Camila Maria Pinheiro de Mello e Silva^1,12 

[1] Corresponding author.;Hospital Israelita Albert Einstein, São Paulo, SP, Brazil;College of Nursing, Departament of Maternal-Infant Nursing and Public Health, Ribeirão Preto, São Paulo, Brazil;Department of Medicine Division of Gastroenterology Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil;Department of Nursing, Federal University of Maranhão, Maranhão, Brazil;Department of Public Health, Federal University of Maranhão, São Luís, MA, Brazil;Division of Infectious Disease, Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil;Federal University of Maranhão, Maranhão, Brazil;Federal University of Maranhão, University College, São Luís, Maranhão, Brazil;Graduate Program of Health Sciences, Federal University of Maranhão, Maranhão, Brazil;Laboratory of Tropical Gastroenterology and Hepatology “João Alves de Queiroz and Castorina Bittencourt Alves”, LIM-07, São Paulo Institute of Tropical Medicine and Department of Gastroenterology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil;Maranhão Clinical Research Center, University Hospital of the Federal University of Maranhão, Maranhão, Brazil;

关键词: Hepatitis B;    Health impact assessment;    Health policy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction and objectives: Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhão, Northeastern Brazil. Materials and methods: A total sample between 3856 and 4000 individuals. Questionnaires were used to register sociodemographic characteristics and factors associated with transmission. Patients were tested for hepatitis B virus surface antigen (HBsAg), anti-hepatitis B core antigen (anti-HBc), and antibodies against hepatitis Delta virus (anti-HDV). Factors associated with HBV were detected by means of multivariate Poisson regression. Results: Overall, 3983 subjects were included. Ninety-two of the participants were HBsAg-positive (2.30%, 95% CI 1.80–2.80), and anti-HBc was detected in 1535 (38.50%, 95% CI 37–40). The factors associated with the presence of anti-HBc were: (1) Municipality (P < 0.001); Age (P < 0.001); School education (P < 0.001); Illicit drug use (P = 0.001); non-HBV vaccine (P = 0.041). Among the HBsAg carriers, eight were anti-HDV-positive (8.69%, 95% CI 2.90–14.40). The most frequent HBV genotype was D4. The only HDV genotype was HDV-8. Conclusion: HBV exhibited intermediate endemicity in the studied region. Traditional factors were associated with exposure to the virus. The presence of the HDV was confirmed. The most frequent HBV and HDV genotypes were unlike the ones currently described in Brazil.

【 授权许可】

Unknown