DQ2, DQ7 and DQ8 Distribution and Clinical Manifestations in Celiac Cases and Their First-Degree Relatives

Nutrients

Yalda Lucero¹  Nelly Espinosa²  Amaya Oyarzun³  Magdalena Araya³  Francisco Pérez-Bravo⁴ 

[1] Department of Pediatrics, Faculty of Medicine, University of Chile, Santiago, Chile;Hospital Militar, Santiago, Chile;Human Nutrition, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile;Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile;

关键词: celiac disease;    first degree relatives;    HLA- DQ2;    HLA-DQ7;    HLA-DQ8;   

DOI  :  10.3390/nu7064955

来源: DOAJ

【 摘 要 】

HLA-linked genes are relevant to celiac disease (CD); the potential genetic differences present worldwide are not fully understood. Previous results suggest that the distribution of HLA-DQ2/DQ7/DQ8 in Chile may differ from that in Europe and North America. In celiac patients and their first-degree relatives (FDRS), we assessed their clinical, serological and histological characteristics, determined HLA-DQ2, HLA-DQ7 andHLA-DQ8 alleles and genotypes, and evaluated the relations between them. A total of222 individuals were assessed (56 cases, 166 FDRs). 16.9% of FDRs were tTG positive; 53.6% of them showed overweight/obesity and 3% undernourishment; they spontaneously declared being asymptomatic, but detailed questioning revealed that 60.7% experienced symptoms, which had not been investigated. DQ2 was present in 53.9% and 43.9.0% of cases and FDRs (p < 0.05). The most frequent genotype distribution was DQ2/DQ7 (fr 0.392 (cases) and 0.248 (FDRs), respectively, p < 0.02). The next most common genotypes were HLA-DQ2/DQ8 (fr 0.236 in FDRs and 0.176 in cases, p < 0.05). 3.92% cases were notHLA-DQ2/DQ8 carriers. Among tTG positive FDRs, 57.4%, 22.3% and 20.2% carried DQ2, DQ7 and DQ8, respectively. In cases, 72.7% of the biopsies classified Marsh ≥3 carried at least one DQ2; 91.7% of DQ2/DQ2 and 88.3% of DQ2/DQ7 were Marsh ≥3. Thus, DQ2 frequency is lower than reported; the higher frequency found for DQ8 and DQ7 concur with recent publications from Argentine and Brazil. These results suggest that although CD may manifest clinically in ways similar to those described in other populations, some genetic peculiarities in this region deserve further study.

【 授权许可】

Unknown