Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach

Nutrients

Gianna Ferretti²  Tiziana Bacchetti¹  Simona Masciangelo¹ 

[1] Department of Life and Environmental Sciences, Polytechnic University of Marche, via Ranieri 65, 60100 Ancona, Italy;Department of Odontostomatologic and Specialistic Clinics Sciences, Polytechnic University of Marche, via Ranieri 65, 60100 Ancona, Italy;

关键词: celiac disease;    gliadin peptides;    nutrigenetic;    nutrigenomic;    proteomic;    fitonutrients;    oxidative stress;    inflammation;   

DOI  :  10.3390/nu4040243

来源: mdpi

【 摘 要 】

Celiac disease (CD), a common heritable chronic inflammatory condition of the small intestine caused by permanent intolerance to gluten/gliadin (prolamin), is characterized by a complex interplay between genetic and environmental factors. Developments in proteomics have provided an important contribution to the understanding of the biochemical and immunological aspects of the disease and the mechanisms involved in toxicity of prolamins. It has been demonstrated that some gliadin peptides resistant to complete proteolytic digestion may directly affect intestinal cell structure and functions by modulating gene expression and oxidative stress. In recent years, the creation of the two research fields Nutrigenomics and Nutrigenetics, has enabled the elucidation of some interactions between diet, nutrients and genes. Various dietary components including long chain ω-3 fatty acids, plant flavonoids, and carotenoids have been demonstrated to modulate oxidative stress, gene expression and production of inflammatory mediators. Therefore their adoption could preserve intestinal barrier integrity, play a protective role against toxicity of gliadin peptides and have a role in nutritional therapy of celiac disease.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.