The role of extracellular vesicles in cholangiocarcinoma

Cancer Cell International

Bing Bai¹  Ping Yue¹  Jinduo Zhang¹  Gang Su²  Chongfei Huang³  Xun Li³  Wenbo Meng³  Wenkang Fu³  Long Gao³  Jie Cao³  Mingzhen Bai³  Haidong Ma³  Yanyan Lin³ 

[1] Department of Special Minimally Invasive Surgery, The First hospital of Lanzhou University;Institute of Genetics, School of Basic Medical Sciences, Lanzhou University;The First Clinical Medical College, Lanzhou University;

关键词: Cholangiocarcinoma;    Extracellular vesicles;    Exosomes;    Biomarkers;    Therapy;   

DOI  :  10.1186/s12935-020-01526-y

来源: DOAJ

【 摘 要 】

Abstract Cholangiocarcinoma (CCA) is a rare tumor that arises from cholangiocytes, the epithelial cells of the bile duct. The tumor is characterized by insidious onset, high degree of malignancy, poor prognosis and high recurrence rate. Due to the lack of specific biomarkers, it is difficult to diagnose CCA early and evaluate prognosis. Extracellular vesicles (EVs), which include apoptotic bodies, microvesicles and exosomes, have emerged as having important roles in cell-to-cell communication in both normal physiology and pathological conditions. Some research has found that EVs play a crucial role in the occurrence and development of CCA. EVs can carry specific molecular substances such as nucleic acids and proteins, which have potential for the diagnosis and therapy of CCA. This article reviews the current knowledge on the role of EVs in CCA. We highlight EVs and their functions in the physiology and pathophysiology of CCA, and discuss their therapeutic potential and their role as biomarkers.

【 授权许可】

Unknown