Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study

Nutrients

Adela Castelló¹  Nuria Aragonés²  Pilar Amiano²  Juan Alguacil²  Dolores Salas-Trejo²  Gemma Castaño-Vinyals²  Esther García-Esquinas²  Manolis Kogevinas²  Beatriz Pérez-Gómez²  Guillermo Fernández-Tardón³  Dora Romaguera³  Inés Gómez-Acebo³  Esther Gracia-Lavedan³  Marina Pollán³  Inmaculada Salcedo-Bellido³  Javier Llorca³  Pablo Fernández-Navarro³  Enrique Gutiérrez-González⁴ 

[1] Preventive Medicine Teaching Unit, National School of Public Health, Carlos III Institute of Health, 28029 Madrid, Spain;Public Health (CIBER en Epidemiología y Salud Pública—CIBERESP), 28029 Madrid, Spain;;Consortium for Biomedical Research in Epidemiology &;Public Health &

关键词: dietary zinc;    prostate cancer;    diet;    genetic susceptibility;   

DOI  :  10.3390/nu11010018

来源: DOAJ

【 摘 要 】

Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00⁻1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18⁻2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00⁻1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89⁻2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility might also have a higher risk of PC associated with this nutrient intake.

【 授权许可】

Unknown