Artificial Cells, Nanomedicine, and Biotechnology | |
Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model | |
He Tian1  Guohua Wei2  Liang Zhao3  Tao Wang3  Mengdie Li3  Yijie Shi3  | |
[1] Department of Histology and Embryology, Jinzhou Medical University, Jinzhou, P R China;Department of Pathology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, P R China;School of Pharmacy, Jinzhou Medical University, Jinzhou, P R China; | |
关键词: Diabetes; inflammation; wound healing; exosomes; angiogenesis; | |
DOI : 10.1080/21691401.2019.1669617 | |
来源: DOAJ |
【 摘 要 】
Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the wound-healing process by inducing endothelial cell proliferation and migration to improve angiogenesis and re-epithelialization in diabetic wounds.
【 授权许可】
Unknown