Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model

Artificial Cells, Nanomedicine, and Biotechnology

He Tian¹  Guohua Wei²  Liang Zhao³  Tao Wang³  Mengdie Li³  Yijie Shi³ 

[1] Department of Histology and Embryology, Jinzhou Medical University, Jinzhou, P R China;Department of Pathology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, P R China;School of Pharmacy, Jinzhou Medical University, Jinzhou, P R China;

关键词: Diabetes;    inflammation;    wound healing;    exosomes;    angiogenesis;   

DOI  :  10.1080/21691401.2019.1669617

来源: DOAJ

【 摘 要 】

Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the wound-healing process by inducing endothelial cell proliferation and migration to improve angiogenesis and re-epithelialization in diabetic wounds.

【 授权许可】

Unknown