Gels | |
Recent Studies on Hydrogels Based on H2O2-Responsive Moieties: Mechanism, Preparation and Application | |
Qi Yang1  Weihua Song1  Jin Jiao1  Jipeng You1  Yuangong Zhang2  Hailei Zhang2  | |
[1] Affiliated Hospital of Hebei University, Baoding 071000, China;College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China; | |
关键词: stimuli-responsive; drug delivery; halloysite nanotube; biomedical; self-crosslinking; difunctional crosslinkers; | |
DOI : 10.3390/gels8060361 | |
来源: DOAJ |
【 摘 要 】
H2O2 is essential for cellular processes and plays a vital role in the regulation of cell signaling pathways, which can be viewed as a warning signal for many kinds of disease including cancer, cardiovascular disease, reproductive abnormalities, diabetes, and renal failure. A H2O2-responsive hydrogel (H2O2-Gel) is a promising candidate for biomedical applications because of its good biocompatibility, similarity to soft biological tissues, ease of preparation, and its ability to respond to H2O2. In this study, the H2O2-responsive moieties used to fabricate H2O2-Gels were reviewed, including thioethers, disulfide bonds, selenides, diselenium bonds, diketones, boronic, and others. Next, the preparation method of H2O2-Gel was divided into two major categories according to their reaction mechanisms: either self-crosslinking or mechanisms entailing the addition of difunctional crosslinkers. Last, the applications of H2O2-Gels were emphasized, which have been viewed as desirable candidates in the fields of drug delivery, the detection of H2O2, glucose-responsive systems, ROS scavengers, tissue engineering, and cell-encapsulation.
【 授权许可】
Unknown