Severe chronic osteomyelitis caused by Morganella morganii with high population diversity

International Journal of Infectious Diseases

Minshan Liu¹  Fan Bai¹  Ruoyan Li¹  Min Yang²  Haifeng Li³  Li Li⁴  Jialiang Zhu⁴  Lin Yang⁴  Shuxun Hou⁴  Wenfeng Li⁴  Ronggong Yang⁴  Li Feng⁵  Yuehua Ke⁶ 

[1] Biodynamic Optical Imaging Center, School of Life Science, Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, China;Construction Engineering Research Institute, Xi’an, Shaanxi Province, China;Department of Medical Affairs, General Hospital of Beijing Military Region of PLA, Beijing, China;Department of Orthopedics, First Affiliated Hospital of PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China;Department of Surgery Room, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, China;Institute of Disease Control and Prevention, AMMS, No. 20, Dongdajie, Fengtai District, Beijing 100071, China;

关键词: Chronic osteomyelitis;    Morganella;    Genetic diversity;    Whole-genome sequencing;   

DOI  :  10.1016/j.ijid.2016.07.016

来源: DOAJ

【 摘 要 】

A case of chronic osteomyelitis probably caused by Morganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population structure analysis of the isolates from the patient showed the bacterial population to be highly diverse. This case provides a valuable example of a long-term infection caused by an opportunistic pathogen, M. morganii, with high diversity, which might evolve during replication within the host.

【 授权许可】

Unknown