Regulation of fetal male germ cell development by members of the TGFβ superfamily

Stem Cell Research

Cassy Spiller¹  Josephine Bowles¹  Guillaume Burnet¹ 

[1] School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia;

关键词: Germ cells;    TGFβ;    Activins;    Nodal;    Cripto;   

DOI  :  10.1016/j.scr.2017.07.016

来源: DOAJ

【 摘 要 】

There is now substantial evidence that members of the transforming growth factor-β (TGFβ family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of testicular germ cell cancer in later life. Here we consider the evidence for involvement of various TGFβ family members, attempt to reconcile discrepancies and clarify what we believe to be the likely in vivo roles of these factors.

【 授权许可】

Unknown