Proinsulin is sensitive to reflect glucose intolerance

Journal of Diabetes Investigation

Yasuo Terauchi¹  Shigekazu Ukawa²  Koshi Nakamura²  Akiko Tamakoshi²  Akinobu Nakamura³  Tatsuya Atsumi³  Hideaki Miyoshi⁴  Takafumi Nakagawa⁵ 

[1] Department of Endocrinology and Metabolism Graduate School of Medicine Yokohama City University Yokohama Japan;Department of Public Health Faculty of Medicine and Graduate School of Medicine Hokkaido University Graduate School of Medicine SapporoJapan;Department of Rheumatology, Endocrinology and Nephrology Faculty of Medicine and Graduate School of Medicine Hokkaido University Graduate School of Medicine Sapporo Japan;Division of Diabetes and Obesity Faculty of Medicine and Graduate School of Medicine Hokkaido University Graduate School of Medicine Sapporo Japan;The Hokkaido Centre for Family Medicine SapporoJapan;

关键词: β‐Cell function;    Epidemiology;    Proinsulin;   

DOI  :  10.1111/jdi.13106

来源: DOAJ

【 摘 要 】

Abstract Aims/Introduction We investigated associations between glucose tolerance and β‐cell function using a series of estimation methods in a population‐based study. Materials and Methods Data from the Dynamics of Lifestyle and Neighborhood Community on Health Study were analyzed. A total of 489 participants (263 women) were divided into three groups: normal glucose tolerance (NGT), prediabetes (PDM) and diabetes group. We estimated β‐cell function by the homeostasis model assessment of β‐cell function, proinsulin level (PI), C‐peptide index, proinsulin‐to‐C‐peptide ratio (PI/CPR) and proinsulin‐to‐insulin ratio. Because data on all five parameters of β‐cell function showed skewed distributions, the values of these parameters were normalized by natural logarithmic (ln) transformation. Next, the association between glucose tolerance and β‐cell function among participants without diabetes was examined. In this analysis, glucose tolerance was assessed based on glycated hemoglobin levels. Results In the crude analysis, ln(PI) and ln(PI/CPR) were significantly higher in the diabetes group than those in the PDM and NGT groups, and these parameters were significantly higher in the PDM group than in the NGT group. Only ln(PI) in the PDM group was significantly higher compared with that in the NGT group after adjustment for age, sex and body mass index (ln[PI]: PDM group 2.38 pmol/L, 95% confidence interval 2.29–2.47 pmol/L; NGT group 2.17 pmol/L, 95% confidence interval 2.12–2.22 pmol/L; P < 0.05). In addition, ln(PI) levels were significantly and positively correlated with glycated hemoglobin quartile in participants without diabetes. Conclusions Our results showed that PI was the most sensitive to reflect glucose intolerance.

【 授权许可】

Unknown