Aquaporin-4 and Cerebrovascular Diseases

International Journal of Molecular Sciences

Xiaobo Yang¹  Qiang Dong¹  Heling Chu¹  Zidan Gao¹  Jing Dong¹  Hongyan Ding¹  Yuping Tang¹  Chuyi Huang² 

[1] Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No. 12 Mid. Wulumuqi Road, Shanghai 200040, China;Department of Neurology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, No. 600 Yishan Road, Shanghai 200030, China;

关键词: aquaporin-4;    cerebral ischemia;    intracerebral hemorrhage;    subarachnoid hemorrhage;   

DOI  :  10.3390/ijms17081249

来源: DOAJ

【 摘 要 】

Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema. Considering brain edema is an important pathophysiological change after stoke, AQP4 is destined to have close relation with cerebrovascular diseases. However, this relation is not limited to brain edema due to other biological effects elicited by AQP4. Till now, multiple studies have investigated roles of AQP4 in cerebrovascular diseases. This review focuses on expression of AQP4 and the effects of AQP4 on brain edema and neural cells injuries in cerebrovascular diseases including cerebral ischemia, intracerebral hemorrhage and subarachnoid hemorrhage. In the current review, we pay more attention to the studies of recent years directly from cerebrovascular diseases animal models or patients, especially those using AQP4 gene knockout mice. This review also elucidates the potential of AQP4as an excellent therapeutic target.

【 授权许可】

Unknown