Aspergillus Section Fumigati Pneumonia and Oxalate Nephrosis in a Foal

Pathogens

Emil Gjurcevic¹  Giovanni Lanteri²  Jasmine Hattab³  Pietro Giorgio Tiscar³  Umberto Tosi³  Giuseppe Marruchella³  Antonella Vulcano⁴  Silvia D’Arezzo⁴  Fabiana Verni⁵ 

[1] Department for Biology and Pathology of Fish and Bees, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia;Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Viale G. Palatucci, 98168 Messina, Italy;Faculty of Veterinary Medicine, University of Teramo, Loc. Piano d’Accio, 64100 Teramo, Italy;Laboratorio di Microbiologia Banca Biologica e Cell Factory, Istituto Nazionale Malattie Infettive “Lazzaro Spallanzani”, via Portuense 292, 00149 Rome, Italy;Veterinary Practitioner, Loc. Convento, 64023 Teramo, Italy;

关键词: horse;    pulmonary aspergillosis;    Aspergillus section Fumigati;    oxalate nephrosis;   

DOI  :  10.3390/pathogens10091087

来源: DOAJ

【 摘 要 】

Equine pulmonary aspergillosis is a rare deep mycosis often due to the hematogenous spread of hyphae after gastrointestinal tract disease. We describe herein the main clinic-pathological findings observed in a foal, which spontaneously died after showing diarrhea and respiratory distress. Necropsy and histopathological investigations allowed to diagnose pulmonary aspergillosis, which likely developed after necrotic typhlitis-colitis. Biomolecular studies identified Aspergillus section Fumigati strain as the causative agent. Notably, severe oxalate nephrosis was concurrently observed. Occasionally, oxalate nephropathy can be a sequela of pulmonary aspergillosis in humans. The present case report suggests that the renal precipitation of oxalates can occur also in horses affected by pulmonary aspergillosis and could likely contribute to the fatal outcome of the disease.

【 授权许可】

Unknown