Immunomodulatory Effects of Green Tea Polyphenols

Molecules

Chi-Tang Ho¹  Yan Liu²  Shuzhen Wang²  Zhiliang Li²  Yuting Ma²  Shiming Li²  Jianfeng Zhan²  Chi-Chen Lin³ 

[1] Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA;Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Zhongke Research Institute of Industrial Technology, College of Life Science, Huanggang Normal University, Huanggang 438000, China;Institute of Biomedical Science, The iEGG and Animal Biotechnology Center, National Chung-Hsing University, Taichung 402, Taiwan;

关键词: green tea polyphenols;    immunomodulatory;    autoimmune diseases;    anti-inflammatory action;    epigallocatechin-3-gallate (EGCG);   

DOI  :  10.3390/molecules26123755

来源: DOAJ

【 摘 要 】

Green tea and its bioactive components, especially polyphenols, possess many health-promoting and disease-preventing benefits, especially anti-inflammatory, antioxidant, anticancer, and metabolic modulation effects with multi-target modes of action. However, the effect of tea polyphenols on immune function has not been well studied. Moreover, the underlying cellular and molecular mechanisms mediating immunoregulation are not well understood. This review summarizes the recent studies on the immune-potentiating effects and corresponding mechanisms of tea polyphenols, especially the main components of (–)-epigallocatechin-3-gallate (EGCG) and (–)-epicatechin-3-gallate (ECG). In addition, the benefits towards immune-related diseases, such as autoimmune diseases, cutaneous-related immune diseases, and obesity-related immune diseases, have been discussed.

【 授权许可】

Unknown