Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review

Frontiers in Oncology

Shiqiao Peng¹  Chenyan Li¹  Xuren Sun²  Yiling Li²  Xiuying Xu²  Minmin Chen²  Mengyuan Liu³  Mingjun Sun³ 

[1] Department of Endocrinology and Metabolism, First Hospital of China Medical University, Shenyang, China;Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China;Department of Gastrointestinal Endoscopy, First Affiliated Hospital of China Medical University, Shenyang, China;

关键词: colitis;    fecal microbiota transplantation;    immune checkpoint inhibitors;    case report;    immunotherapy;   

DOI  :  10.3389/fonc.2022.913217

来源: DOAJ

【 摘 要 】

Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palatal malignant melanoma who developed diarrhea and hematochezia accompanied by fever, gastrointestinal bleeding, and infection after the third treatment with PD-1 (Toripalimab). The patient received general treatment unsuccessful, corticosteroid therapy after initial success but rapid loss of response, and finally successful treatment after fecal microbiota transplantation.

【 授权许可】

Unknown