Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis

Frontiers in Cellular and Infection Microbiology

Qiong Wang¹  Jinyong Zhou²  Lei Zhu³  Guoping Shi³  Rong Wang⁴  Fan Bu⁴  Zhenglan Duan⁴  Xiaomin Yuan⁴  Zeyu Feng⁴  Yang Ding⁴  Yugen Chen⁴  Qing Ni⁵  Tuo Chen⁵  Li Liu⁶ 

[1] Basic Pharmacology Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;Central Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;Collaborative Innovation Center for Cancer Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;Department of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;Department of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, China;Glycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China;

关键词: chronic restraint stress;    colitis;    colonic mucus;    fecal microbiota transplantation;    Akkermansia muciniphila;   

DOI  :  10.3389/fcimb.2021.723856

来源: Frontiers

【 摘 要 】

Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in microbiota composition, disruption of colonic mucus, and aggravation of colitis. In addition, the abundance of Akkermansia muciniphila was significantly decreased in mice under CRS and UC patients with depression, and positively associated with the expression of MUC2. After antibiotic treatment, the recipient mice colonized with CRS microbiota showed barrier defects and severe colitis. Administration of Akkermansia muciniphila was found to restore colonic mucus and modify the gut microbiota. We confirm that CRS-mediated gut microbiota dysbiosis results in colonic mucosal barrier damage and aggravation of colitis. Our results suggest that A. muciniphila is expected to be a potential probiotic to protect and treat colonic mucus that is involved in IBD with psychological disorders.

【 授权许可】

CC BY