期刊论文详细信息
Frontiers in Chemistry | |
The association constant of 5',8-cyclo-2'-deoxyguanosine with cytidine | |
Annalisa eMasi1  Michael A. Terzidis1  Chryssostomos eChatgilialoglu2  Andrea ePeluso3  Tonino eCaruso3  Sandra eFusco3  Amedeo eCapobianco3  | |
[1] Consiglio Nazionale delle Ricerche;NCSR Demokritos;Università di Salerno; | |
关键词: DNA Damage; Voltammetry; NMR; cyclopurines; Watson-Crick complex; | |
DOI : 10.3389/fchem.2015.00022 | |
来源: DOAJ |
【 摘 要 】
The association of 5',8-cyclo-2'-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanosine, the difference being approximately of one order of magnitude between the two association constants.
【 授权许可】
Unknown