The association constant of 5',8-cyclo-2'-deoxyguanosine with cytidine

Frontiers in Chemistry

Annalisa eMasi¹  Michael A. Terzidis¹  Chryssostomos eChatgilialoglu²  Andrea ePeluso³  Tonino eCaruso³  Sandra eFusco³  Amedeo eCapobianco³ 

[1] Consiglio Nazionale delle Ricerche;NCSR Demokritos;Università di Salerno;

关键词: DNA Damage;    Voltammetry;    NMR;    cyclopurines;    Watson-Crick complex;   

DOI  :  10.3389/fchem.2015.00022

来源: DOAJ

【 摘 要 】

The association of 5',8-cyclo-2'-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanosine, the difference being approximately of one order of magnitude between the two association constants.

【 授权许可】

Unknown