Feeding the Outer Bran Fraction of Rice Alters Hepatic Carbohydrate Metabolism in Rats

Nutrients

Nao Nishikoba¹  Akira Ohtsuka¹  Saki Shimamoto¹  Rukana Kohrogi¹  Mana Kawaguchi¹  Daichi Ijiri¹  Shozo Tomonaga²  Yoko Yamauchi³  Yoshikazu Fujita³ 

[1] Department of Biochemical Science and Technology, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan;Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan;Shokkyo Co., Ltd., 5-9 Matsukawacho, Minami-ku, Hiroshima 732-0826, Japan;

关键词: metabolomics;    rice bran;    short-chain fatty acid;    fatty acid synthesis;    gluconeogenesis;   

DOI  :  10.3390/nu12020430

来源: DOAJ

【 摘 要 】

Dietary intake of fiber-rich food has been reported to contribute to multiple health benefits. The aim of the current study is to investigate the effects of a diet containing the outer bran fraction of rice (OBFR), which is rich in insoluble fiber, on the intestinal environment and metabolite profiles of rats. Fourteen 8-week-old male Sprague−Dawley rats were divided into a control group and an OBFR group. For a period of 21 days, the control group was fed a control diet, while the OBFR group was fed a diet containing 5% OBFR. Metabolomics analysis revealed drastic changes in the cecal metabolites of the rats fed the OBFR diet. Furthermore, in the plasma and liver tissue, the concentrations of metabolites involved in pyruvate metabolism, the pentose phosphate pathway, gluconeogenesis, or valine, leucine, isoleucine degradation were changed. Concordantly, the OBFR diet increased the expression of genes encoding enzymes involved in these metabolic pathways in the livers of the rats. Collectively, these results suggest that the OBFR diet altered the concentrations of metabolites in the cecal contents, plasma, and liver, and the hepatic gene expressions of rats, and that this may have mainly contributed to carbohydrate metabolism in the liver.

【 授权许可】

Unknown