Laurus nobilis: Composition of Essential Oil and Its Biological Activities

Molecules

Laura De Martino¹  Lucéia Fatima Souza¹  Luigi Aliberti¹  Lucia Caputo¹  Vincenzo De Feo¹  Raffaele Coppola²  Filomena Nazzaro³  Florinda Fratianni³ 

[1] Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy;Dipartimento di Agricoltura, Ambiente e Alimenti-Università del Molise, Via de Sanctis snc, 86100 Campobasso, Italy;Istituto di Scienze dell’Alimentazione, Consiglio Nazionale delle Ricerche (ISA-CNR), Via Roma 64, 83100 Avellino, Italy;

关键词: Laurus nobilis L.;    essential oil;    antibacterial activity;    antifungal activity;    cytotoxicity;    adenylate cyclase 1 (ADCY1);    Central Nervous System (CNS);   

DOI  :  10.3390/molecules22060930

来源: DOAJ

【 摘 要 】

Laurus nobilis is native to the southern Mediterranean region and cultivated mainly in Europe and the USA as an ornamental and medicinal plant. The chemical composition of the essential oil (EO) from leaves of L. nobilis, collected in Southern Italy, was studied by GC and GC-MS. In all, 55 compounds were identified, accounting for 91.6% of the total oil. 1,8-Cineole (31.9%), sabinene (12.2%), and linalool (10.2%) were the main components. Antimicrobial and antifungal activities of EO and 1,8-cineole were determined in vitro. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line, as well as the influence of the EO on the expression of adenylate cyclase 1 (ADCY1), suggesting possible oil effects on the Central Nervous System.

【 授权许可】

Unknown