A Pan-Cancer Analysis of Transcriptome and Survival Reveals Prognostic Differentially Expressed LncRNAs and Predicts Novel Drugs for Glioblastoma Multiforme Therapy

Frontiers in Genetics

Jinhui Gu¹  Xiaohan Sa³  Nan Ouyang³  Jiao Yang³  Jinlin Pan³  Yuanshuai Zhou³  Rongchuan Zhao³  Hong Zhang⁴ 

[1] Department of Anorectum, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, China;Division of Life Sciences and Medicine, School of Biomedical Engineering (Suzhou), University of Science and Technology of China, Heifei, China;Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China;School of Life Sciences, Shanghai University, Shanghai, China;

关键词: pan-cancer;    long noncoding RNA;    prognosis;    biomarker;    glioblastoma multiforme;   

DOI  :  10.3389/fgene.2021.723725

来源: DOAJ

【 摘 要 】

Numerous studies have identified various prognostic long non-coding RNAs (LncRNAs) in a specific cancer type, but a comprehensive pan-cancer analysis for prediction of LncRNAs that may serve as prognostic biomarkers is of great significance to be performed. Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. There is an urgent need to identify novel therapies for GBM due to its poor prognosis and universal recurrence. Using available LncRNA expression data of 12 cancer types and survival data of 30 cancer types from online databases, we identified 48 differentially expressed LncRNAs in cancers as potential pan-cancer prognostic biomarkers. Two candidate LncRNAs were selected for validation in GBM. By the expression detection in GBM cell lines and survival analysis in GBM patients, we demonstrated the reliability of the list of pan-cancer prognostic LncRNAs obtained above. By constructing LncRNA-mRNA-drug network in GBM, we predicted novel drug-target interactions for GBM correlated LncRNA. This analysis has revealed common prognostic LncRNAs among cancers, which may provide insights into cancer pathogenesis and novel drug target in GBM.

【 授权许可】

Unknown